Biological Activity for Substance P

Substance p is a sensory neuropeptide và inflammatory mediator. Exerts excitatory effects on central & peripheral neurons, constricts bronchioles and is involved in pain transmission.

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Technical Data for Substance P

M. Wt 1347.6
Formula C63H98N18O13S
Sequence RPKPQQFFGLM

(Modifications: Met-11 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 33507-63-0
PubChem ID 36511
InChI Key ADNPLDHMAVUMIW-CUZNLEPHSA-N
Smiles NH>(CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to lớn the Certificate of Analysis.

ionianisia-region.com products are intended for laboratory research use only, unless stated otherwise.


References for Substance P

References are publications that support the biological activity of the product.

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Andoh et al (1998) Substance p. Induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice. J.Pharmacol.Exp.Ther. 286 1140 PMID:9732370 Pernow et al (1983) Substance p Pharmacol.Rev. 35 85 PMID:6196797 Walsh et al (1995) Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br.J.Pharmacol. 114 1343 PMID:7541689 Merck Index 12 9032 If you know of a relevant reference for Substance P, please let us know.


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Keywords: Substance P, Substance p. Supplier, Sensory, neuropeptide, inflammatory, mediators, Tachykinin, Non-Selective, Neurokinin, Receptors, agonists, SubstanceP, neuropeptides, Other, 1156, ionianisia-region.com Bioscience


15 Citations for Substance P

Citations are publications that use ionianisia-region.com products. Selected citations for Substance phường include:

Wease & Davies (2005) Substance phường selectively decreases paired pulse depression in the rat hippocampal slice. BMC Neurosci 6 66 PMID:16305744

Alsaqati et al (2013) Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal 10 241 PMID:24310605

Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin và oxyt. Neurons. J Biomol Screen 24 10103 PMID:15537880

Gutierrez and Boada (2019) Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+). Cancer Cell Int 18 216 PMID:30598641


Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID:28954865

Hur & Park (2013) Long-term potentiation of excitatory synaptic strength in spinothalamic tract neurons of the rat spinal cord. Korean J Physiol Pharmacol 17 553 PMID:24381506

Hanson et al (2009) A homogeneous fluorescent live-cell assay for measuring 7-transmembrane receptor activity and agonist functional selectivity through β-arrestin recruitment. Antioxid Redox Signal 14 798 PMID:19531663

Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperDA và D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J Neurosci 29 15551 PMID:20007479

Wan et al (2017) Endomorphin-2 Inhibition of Substance p. Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats. Front Mol Neurosci 9 167 PMID:28119567

Fisher et al (2015) Increased CCN2, substance phường and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury. J Cell Commun Signal 9 37 PMID:25617052

Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439 PMID:21931717

Shanley et al (2011) Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones. J Neurosci 8 10 PMID:21294877

Kowtharapu et al (2018) Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing. Int J Mol Sci 19 PMID:29401709

Frara et al (2018) Substance p. Increases CCN2 dependent on TGF-beta yet Collagen Type I via TGF-beta1 dependent & independent pathways in tenocytes. Connect Tissue Res 59 30 PMID:28399671

Chen et al (2014) μ-Opioid receptor inhibition of substance p release from primary afferents disappears in neuropathic pain but not inflammatory pain. Neuroscience 267 67 PMID:24583035